• Title Target product profiles for point-of-care TB testing
  • Granting Agency Bill & Melinda Gates Foundation
  • Period 1 Aug. 2012 – 31 July 2015
  • Amount $1,190,749 USD

This project developed target product profiles (TPPs) for point-of-care (POC) TB testing, to accelerate further development and validation work in this area.

Publications

Yellapa, Vijayashree; Devadasan, Narayanan; Krumeich, Anja; Pai, Nitika Pant; Vadnais, Caroline; Pai, Madhukar; Engel, Nora

How patients navigate the diagnostic ecosystem in a fragmented health system: a qualitative study from India (Journal Article)

In: Global Health Action, vol. 10, no. 1, pp. 1350452, 2017, (PMID: 28762894).

(Links)

Zhao, YL; Pang, Y; Xia, H; Du, X; Chin, D; Huan, ST; Dong, HY; Zhang, ZY; Ginnard, J; Perkins, MD; others,

Market assessment of tuberculosis diagnostics in China in 2012. (Journal Article)

In: The International Journal of Tuberculosis and Lung Disease, vol. 20, no. 3, pp. 295–303, 2016.

(Links)

Maheshwari, P; Chauhan, K; Kadam, R; Pujani, A; Kaur, M; Chitalia, M; Dabas, H; Perkins, MD; Boehme, CC; Denkinger, CM; others,

Market assessment of tuberculosis diagnostics in India in 2013 (Journal Article)

In: The International Journal of Tuberculosis and Lung Disease, vol. 20, no. 3, pp. 304–313, 2016.

(Links)

Murrison, Liza Bronner; Ananthakrishnan, Ramya; Sukumar, Sumanya; Augustine, Sheela; Krishnan, Nalini; Pai, Madhukar; Dowdy, David W

Use of Rapid, Point-of-Care Assays by Private Practitioners in Chennai, India: Priorities for Tuberculosis Diagnostic Testing (Journal Article)

In: PLoS One, vol. 11, no. 6, pp. e0155775, 2016.

(Links)

Murrison, Liza Bronner; Ananthakrishnan, Ramya; Sukumar, Sumanya; Augustine, Sheela; Krishnan, Nalini; Pai, Madhukar; Dowdy, David W

How Do Urban Indian Private Practitioners Diagnose and Treat Tuberculosis? A Cross-Sectional Study in Chennai (Journal Article)

In: PLoS One, vol. 11, no. 2, pp. e0149862, 2016.

(Links)

Murrison, L Bronner; Ananthakrishnan, R; Swaminathan, A; Auguesteen, S; Krishnan, N; Pai, M; Dowdy, David Wesley

How do patients access the private sector in Chennai, India? An evaluation of delays in tuberculosis diagnosis (Journal Article)

In: The International Journal of Tuberculosis and Lung Disease, vol. 20, no. 4, pp. 544–551, 2016.

(Links)

Consortium, TB Diagnostics Market Analysis; others,

Market assessment of tuberculosis diagnostics in South Africa, 2012-2013 (Journal Article)

In: The International Journal of Tuberculosis and Lung Disease, vol. 19, no. 2, pp. 216, 2015.

(Links)

Davids, Malika; Dheda, Keertan; Pai, Nitika Pant; Cogill, Dolphina; Pai, Madhukar; Engel, Nora

A survey on use of rapid tests and tuberculosis diagnostic practices by primary health care providers in South Africa: implications for the development of new point-of-care tests (Journal Article)

In: PLoS One, vol. 10, no. 10, pp. e0141453, 2015.

(Links)

Engel, Nora; Ganesh, Gayatri; Patil, Mamata; Yellappa, Vijayashree; Pai, Nitika Pant; Vadnais, Caroline; Pai, Madhukar

Barriers to point-of-care testing in India: results from qualitative research across different settings, users and major diseases (Journal Article)

In: PLoS One, vol. 10, no. 8, pp. e0135112, 2015.

(Links)

Schumacher, SG; Thangakunam, B; Denkinger, CM; Oliver, AA; Shakti, KB; Qin, ZZ; Michael, JS; Luo, R; Pai, M; Christopher, DJ

Impact of point-of-care implementation of Xpert MTB/RIF: product vs. process innovation (Journal Article)

In: The International Journal of Tuberculosis and Lung Disease, vol. 19, no. 9, pp. 1084–1090, 2015.

(Links)

Kik, Sandra V; Denkinger, Claudia M; Jefferson, Carole; Ginnard, Janet; Pai, Madhukar

Potential market for novel tuberculosis diagnostics: worth the investment? (Journal Article)

In: Journal of Infectious Diseases, vol. 211, no. suppl 2, pp. S58–S66, 2015.

(Links)

Engel, Nora; Davids, Malika; Blankvoort, Nadine; Pai, Nitika Pant; Dheda, Keertan; Pai, Madhukar

Compounding diagnostic delays: a qualitative study of point-of-care testing in South Africa (Journal Article)

In: Tropical medicine & international health, vol. 20, no. 4, pp. 493–500, 2015.

(Links)

Denkinger, Claudia M; Dolinger, David; Schito, Marco; Wells, William; Cobelens, Frank; Pai, Madhukar; Zignol, Matteo; Cirillo, Daniela Maria; Alland, David; Casenghi, Martina; others,

Target product profile of a molecular drug-susceptibility test for use in microscopy centers (Journal Article)

In: Journal of Infectious Diseases, vol. 211, no. suppl 2, pp. S39–S49, 2015.

(Links)

Denkinger, Claudia M; Kik, Sandra V; Cirillo, Daniela Maria; Casenghi, Martina; Shinnick, Thomas; Weyer, Karin; Gilpin, Chris; Boehme, Catharina C; Schito, Marco; Kimerling, Michael; others,

Defining the needs for next generation assays for tuberculosis (Journal Article)

In: Journal of Infectious Diseases, vol. 211, no. suppl 2, pp. S29–S38, 2015.

(Links)

Pai, Madhukar; Schito, Marco

Tuberculosis diagnostics in 2015: landscape, priorities, needs, and prospects (Journal Article)

In: Journal of Infectious Diseases, vol. 211, no. suppl 2, pp. S21–S28, 2015.

(Links)

Jefferson, Carole; Denkinger, Claudia M; Ginnard, Janet; Kik, Sandra; Pai, Madhukar

TB diagnostics market in select high-burden countries: Current market and future opportunities for novel diagnostics (Book)

2015.

(Links)

Salje, Henrik; Andrews, Jason R; Deo, Sarang; Satyanarayana, Srinath; Sun, Amanda Y; Pai, Madhukar; Dowdy, David W

The importance of implementation strategy in scaling up Xpert MTB/RIF for diagnosis of tuberculosis in the Indian health-care system: a transmission model (Journal Article)

In: PLoS Medicine, vol. 11, no. 7, pp. e1001674, 2014.

(Links)

Denkinger, Claudia M; Kik, Sandra V; Pai, Madhukar

Robust, reliable and resilient: designing molecular tuberculosis tests for microscopy centers in developing countries (Journal Article)

In: Expert Review of Molecular Diagnostics, vol. 13, no. 8, pp. 763-767, 2014.

(Links)

Kik, Sandra V; Denkinger, Claudia M; Casenghi, Martina; Vadnais, Caroline; Pai, Madhukar

Tuberculosis diagnostics: which target product profiles should be prioritised? (Journal Article)

In: European Respiratory Journal, vol. 44, no. 2, pp. 537–540, 2014.

(Links)

Satyanarayana, S; Sagili, K; Chadha, SS; Pai, M

Use of rapid point-of-care tests by primary health care providers in India: findings from a community-based survey (Journal Article)

In: Public health action, vol. 4, no. 4, pp. 249–251, 2014.

(Links)

Consortium, TB Diagnostics Market Analysis; others,

Market assessment of tuberculosis diagnostics in Brazil in 2012 (Journal Article)

In: PLoS One, vol. 9, no. 8, pp. e104105, 2014.

(Links)

Kik, Sandra V; Denkinger, Claudia M; Chedore, Pamela; Pai, Madhukar

Replacing smear microscopy for the diagnosis of tuberculosis: what is the market potential? (Journal Article)

In: European Respiratory Journal, vol. 43, no. 6, pp. 1793–1796, 2014.

(Links)

WHO, (Ed.)

High priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting, 28-29 April 2014, Geneva, Switzerland (Technical Report)

2014.

(Links)

Denkinger, Claudia M; Nicolau, Ioana; Ramsay, Andrew; Chedore, Pamela; Pai, Madhukar

Are peripheral microscopy centres ready for next generation molecular tuberculosis diagnostics? (Journal Article)

In: European Respiratory Journal, vol. 42, no. 2, pp. 544–547, 2013.

(Links)

Engel, Nora; Pai, Madhukar

Tuberculosis diagnostics: Why we need more qualitative research (Journal Article)

In: Journal of epidemiology and global health, vol. 3, no. 3, pp. 119–121, 2013.

(Links)

Pai, Madhukar

Diagnostics for tuberculosis: what test developers want to know (Journal Article)

In: Expert Review of Molecular Diagnostics, vol. 13, no. 4, pp. 311–314, 2013.

(Links)

Pai, Nitika Pant; Vadnais, Caroline; Denkinger, Claudia; Engel, Nora; Pai, Madhukar

Point-of-care testing for infectious diseases: diversity, complexity, and barriers in low-and middle-income countries (Journal Article)

In: PLoS Medicine, vol. 9, no. 9, pp. e1001306, 2012.

(Links)